PREDICTGYN

R&D Projects

New approaches in the individualized management of patients with gynecologic cancer

NEW MARKERS

The general aim of this project is the development of new markers for the diagnosis and prediction of gynaecological cancers (endometrial and ovarian), as well as the validation of therapies aimed at these patient populations.

Given the ambition of the project, a number of specific objectives have been defined:

To establish a repository of endometrial and ovarian cancer samples together with clinicopathological and clinical monitoring data.
To identify and validate prognostic markers in ovarian cancer through transcriptomics and proteomics; and in endometrial cancer, through proteomics.
To validate the capacity of a panel of transcriptomic biomarkers to discern the histological subtype and grade of endometrial cancer tumours.
To study and validate the expression profile of prognostic biomarkers of ovarian and endometrial cancer through multiple immunofluorescence.
To determine the prognostic value of recurrence of specific stem cell markers through multiplex immunofluorescence.

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specific objectives guide the project

Predictgyn works to improve diagnosis and prediction for gynaecological cancers

In addition, the project also seeks to improve treatments, and to this end it has set the objectives of testing new therapies for endometrial and ovarian cancer, as well as determining some of the markers identified in objectives 2 and 3 for their subsequent evaluation as a companion diagnostic for personalising treatment.

To achieve the objectives

RTC-2015-3821-1 2015-2018

In order to successfully achieve the project’s aims, a consortium has been formed, led by Ability Pharmaceuticals S.L., in which Oryzon Genomics Diagnóstico S.L. (ODX), Laboratorio Reig Jofré, S.A., Institut de Recerca Biomédica de Lleida, Fundació Privada Dr Pifarré, and Fundació Hospital Universitari Vall d’Hebron – Institut de Recerca all collaborate.

This project is financed by the Ministry of Science, Innovation and Universities within the RETOS-COLABORACIÓN Subprogram, 2015 Call. Co-financed by the European Union with the aim of promoting technological development, innovation and quality research.