R&D Projects


Determination of metabolomic profiles in the early diagnosis of breast cancer.

The aim of the project is to develop a non-invasive method to detect breast cancer early and identify of specific molecular subtypes through metabolomics and miRNA analysis in liquid biopsies. These new methods will help to establish the optimal individualised therapy and predict treatment response in breast cancer patients.

The starting hypothesis is based on the existence of alterations in normal metabolic processes that occur in cancer cells and do not occur in healthy cells. This leads to changes in the normal serum concentrations of certain metabolites that can be easily detected and analysed through blood samples.


methods for the personalised diagnosis and treatment of breast cancer


The project develops a non-invasive method for early detection of breast cancer.

Moreover, many studies have associated changes in the profile of miRNAs (small non-coding RNA sequences that regulate gene expression) with different aspects of breast cancer, including early diagnosis, different histological patterns, and disease prognosis.

The set of altered metabolites and the miRNA profile characteristic of the patients would constitute a “signature” indicating the presence of the tumour, which would allow early detection and a more reliable prognosis of the progression of the disease, helping in the selection and monitoring of treatment.

To achieve the objectives

RTC-2016-5674-1 2016-2019

To ensure the success of the project, a consortium has been set up with the Biosanitary Research Foundation in Eastern Andalusia (FIBAO) and the Medina Foundation Centre of Excellence in Innovative Medicines Research in Andalusia.

The project is co-funded by the Ministry of Economy and Competitiveness, within the call Challenges-Collaboration of the State Programme for Research, Development and Innovation Oriented to the Challenges of Society, in the framework of the State Plan for Scientific and Technical Research and Innovation 2013-2016, and by the European Regional Development Fund (ERDF).

Financial blockers

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