The global fight against the COVID-19 pandemic has revealed the absence of a highly sensitive PoC diagnostic methods to directly detect the virus and without previous sample preparation steps to carry out a rapid, precise and massive diagnosis of the virus. Consequently, PCR diagnosis has been promoted, although its limited diagnostic capacity in absolute terms (fewer tests) due to the intrinsic limitations of the technique added to the lack of supply of reagents and saturation of the laboratories authorized clinicians.
The use of biosensors, especially those based on field effect transistors (FETs), represents an important alternative thanks to their ability to perform highly sensitive and instantaneous measurements from small amounts of sample. Due to its high electronic conductivity and large specific area, graphene has been applied in the production of analytical devices based on FETs (GFETs). The main objective of this project is the development of a fully integrated graphene monolayer PoC biosensor based on FET technology for the rapid and sensitive detection of SARS-CoV-2 on a large scale and using samples collected with nasopharyngeal swabs. The design of the proposed prototype will allow rapid and efficient scaling at the industrial production level.