Research and development

Publications and patents

Atrys has an intense R&D commitment, and allocates a significant portion of its human and material resources to the development of new approaches for personalized diagnosis and translational research.

Some of the R&D activities have generated international patent applications, as well as publications of scientific papers in international journals.

Publications

J Transl Med. (2019)

Polyethilene glycol improves current methods for circulating extracellular vesicle-derived DNA isolation

García-Romero N, Madurga R, Rackov G, Palacín-Aliana I, Núñez-Torres R, Asensi-Puig A, Carrión-Navarro J, Esteban-Rubio S, Peinado H, González-Neira A, González-Rumayor V, Belda-Iniesta C, Ayuso-Sacido A

BMC Res Notes (2019)

Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer

Pere Puig, Nadina Erill, Marta Terricabras, Isaac Subirana, Judit González‑García, Adrià Asensi‑Puig, Michael J. Donovan, Lourdes Mengual, M.Teresa Agulló‑Ortuño, Mireia Olivan, Antonio Alcaraz, José A. López‑Martín, Inés de Torres, José Luis Rodríguez‑Peralto, Alfredo Rodríguez‑Antolín, Juan Morote and Víctor González‑Rumayor

Bioinformatics (2018)

ImaGEO: integrative gene expression meta-analysis from GEO database

Daniel Toro-Domínguez, Jordi Martorell-Marugán, Raúl López-Domínguez, Adrián García-Moreno, Víctor González-Rumayor, Marta E Alarcón-Riquelme, Pedro Carmona-Sáez

Oncotarget. 2015 Apr 30;6(12):10604-16.

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer.

Marín-Aguilera M, Reig Ò, Lozano JJ, Jiménez N, García-Recio S, Erill N, Gaba L, Tagliapietra A, Ortega V, Carrera G, Colomer A, Gascón P, Mellado B.

Arthritis Rheumatol. 2016 Sep 6. doi: 10.1002/art.39857.

Granzyme A contributes to inflammatory arthritis through stimulation of osteoclastogenesis

Santiago L, Menaa C, Arias M, Martin P, Jaime-Sánchez P, Metkar S, Comas L, Erill N, Gonzalez-Rumayor V, Esser E, Galvez EM, Raja S, Simon MM, Sprague SM, Gabay C, Martinez-Lostao L, Pardo J, Froelich CJ

Mol Cancer Ther. 2014 May;13(5):1270-84. doi: 10.1158/1535-7163.MCT-13-0775. Epub 2014 Mar 21.

Epithelial-to-mesenchymal transition mediates docetaxel resistance and high risk of relapse in prostate cancer.

Marín-Aguilera M, Codony-Servat J, Reig Ò, Lozano JJ, Fernández PL, Pereira MV, Jiménez N, Donovan M, Puig P, Mengual L, Bermudo R, Font A, Gallardo E, Ribal MJ, Alcaraz A, Gascón P, Mellado B.

J Neurooncol. 2014 Jan;116(2):413-9. doi: 10.1007/s11060-013-1316-y. Epub 2013 Dec 19.

Efficacy of erlotinib in patients with relapsed gliobastoma multiforme who expressed EGFRVIII and PTEN determined by immunohistochemistry.

Gallego O, Cuatrecasas M, Benavides M, Segura PP, Berrocal A, Erill N, Colomer A, Quintana MJ, Balaña C, Gil M, Gallardo A, Murata P, Barnadas A.

Haematologica. 2013 Oct;98(10): 1554-1562. doi:10.3324/haematol.2013.086173. Epub 2013 May 28

MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.

Valera A, López-Guillermo A, Cardesa-Salzmann T, Climent F, González-Barca E, Mercadal S, Espinosa I, Novelli S, Briones J, Mate JL, Salamero O, Sancho JM, Arenillas L, Serrano S, Erill N, Martínez D, Castillo P, Rovira J, Martínez A, Campo E, Colomo L; Grup per l’Estudi dels Limfomes de Catalunya i Balears (GELCAB)

Inflamm Bowel Dis. 2011 Jul;17(7):1490-500. doi: 10.1002/ibd.21507. Epub 2010 Nov 8.

Apoptosis resistance of mucosal lymphocytes and IL-10 deficiency in patients with steroid-refractory Crohn's disease.

Santaolalla R, Mañé J, Pedrosa E, Lorén V, Fernández-Bañares F, Mallolas J, Carrasco A, Salas A, Rosinach M, Forné M, Espinós JC, Loras C, Donovan M, Puig P, Mañosa M, Gassull MA, Viver JM, Esteve M.

Patents

P7304PC00-PCT/EP2012/067815:

Methods for prognosis of diffuse large b-cell lymphoma

PCT/EP2010/069058:

EGFR and PTEN gene alterations predicts survival in patients with brain tumors

EP14382545.3: